Magic Mushrooms contain psilocybin or psilocin. They can be also referred to as shrooms, golden teachers, mushies, golden tops, Amani, or argaric. Psilocybin and psilocin are naturally occurring hallucinogenic and psychoactive compounds. Psilocybin was first isolated by Dr. Albert Hofmann in 1958. Regular use of shrooms can lead to side effects. This article highlights all one needs to know about shrooms and tolerance.


How Tolerance Affects Your Experience with Psychedelics

Psilocybin is a well-known psychedelic. Psychedelics are some class of hallucinogenic drugs whose effect triggers a non-ordinary state of consciousness. Psilocybin falls under schedule 1 drugs signifying that it has a potential for misuse. It acts via serotonin receptor agonism often causing psychologic auditory and visual changes and an altered level of consciousness. Magic mushrooms look like ordinary mushrooms but have long, slender stems that are whitish gray, dark brown caps with a white or brown center. When dried, they become rusty brown. However, one should be cautious so as not to eat the poisonous mushrooms since some look like psilocybin mushrooms. These poisonous mushrooms tend to damage the liver. There are various ways of ingestion of shrooms. It can be eaten with food or mixed with food. It can also be for drinking. Liquid psilocybin is available and is usually clear brown. They can also be mixed with other drugs such as tobacco or cannabis and then smoked. A powdered form exists, which can be snorted, injected or added to juices.

Once ingested into the body, psilocybin in the mushrooms is converted to psilocin in the body. The compound then acts centrally at the brain as a serotonin receptor agonist, thereby altering serotonin levels in the brain. The effects take twenty to forty minutes to begin and may persist up to six hours. The user experiences hallucinations and altered perceptions. The user may feel, see or hear some sensations that seem real, but in essence, they are not real. Others include a sense of euphoria and a distorted sense of time. However, some people have reported feeling confused, having paranoia, and being anxious rather than being high. Some users who take these substances become paranoid or anxious.

There are also changes in mood, personality, eating, and sleeping patterns in the user. Some users have experienced delusions and panic, while those in the extremes have experienced convulsions. These effects are also influenced by factors such as the dose, age, personality, emotional state, weight, history of mental illness, and the environment. You can easily build up a tolerance for magic mushrooms. All you need to do is allow several days between taking full doses of these substances.


Other Side Effects of Shrooms

Magic mushrooms have been used from the past for spiritual and medicinal uses. It has since been recommended for medical use to treat cancer-associated psychiatric stress, anxiety, depression, substance abuse disorders, and nicotine addiction. Psilocybin is a hallucinogen. Therefore, there is a risk of emotional and mental problems. The side effects encompass both physical and mental changes. Physical effects include muscle weakness, headaches, drowsiness, dilated pupils, nausea, and lack of coordination, increased blood pressure, temperature, and heart rate. Mental effects include euphoria, both auditory and visual hallucinations, paranoia, psychosis, nervousness, panic reactions, and a distorted sense of place, time, and reality. Care has to be taken to avoid poisoning. There have been reported cases of adolescents using magic mushrooms in combination with other drugs such as alcohol, thereby increasing psychological and physical risks.


Continuous use of Shrooms

Continuous use of the drug for three to four days may precipitate tolerance. Tolerance implies that a higher amount of the drug is required by the user to achieve the same effect. Tolerance leads to consumption of a larger amount, which may lead to overdose. Overdose symptoms include diarrhea, vomiting, agitation, muscle weakness, panic, paranoia, seizures, and psychosis. The tolerance with magic mushrooms is lost as fast as it develops. Combined use with drugs such as tobacco leads to an increased risk for drug dependence.

Psilocybin is not addictive, and users rarely report withdrawal symptoms. However, some users have reported psychological disturbances, such as depression. The short term effect wears off in six to twelve hours while it may take longer in others. However, long-term changes in personality and flashbacks persist after taking the drug. The drug also persists in the hair follicles for up to 90 days. Detection of psilocybin in magic mushrooms can be done by reverse-phase liquid chromatography with fluorescence detection.


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